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This triple-agonist mechanism is what makes it potentially more effective than single-agonist peptides like semaglutide , but it also means the gastrointestinal side effects can be more intense if you start too high

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Several studies suggest that high-dose oral supplementation (e.g., 1000 to 2000 mcg daily) can be as effective as injections for some patients, but this depends on individual health status